Crystallization (Comment) | Organism |
---|---|
molecular modeling of type II enzyme in complex with inhibitor 1_1_1.205_2.3 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate | comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation | Homo sapiens | |
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate | comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation | Homo sapiens | |
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate | comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation | Homo sapiens | |
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate | comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation | Homo sapiens | |
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate | comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation | Homo sapiens | |
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate | comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation | Homo sapiens | |
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(2-ethyladenosin-5'-yl)methylenebis(phosphonate) | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000001 | - |
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate | isoform IMPDH1, pH 8.0, 25°C | Homo sapiens | |
0.000007 | - |
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate | isoform IMPDH1, pH 8.0, 25°C | Homo sapiens | |
0.00001 | - |
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate | isoform IMPDH1, pH 8.0, 25°C | Homo sapiens | |
0.000014 | - |
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens | |
0.000019 | - |
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate | isoform IMPDH1, pH 8.0, 25°C | Homo sapiens | |
0.00002 | - |
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate | isoform IMPDH1, pH 8.0, 25°C | Homo sapiens | |
0.000027 | - |
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens | |
0.000049 | - |
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens | |
0.000084 | - |
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens | |
0.00011 | - |
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate | isoform IMPDH1, pH 8.0, 25°C | Homo sapiens | |
0.00011 | - |
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens | |
0.000143 | - |
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens | |
0.04 | - |
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(2-ethyladenosin-5'-yl)methylenebis(phosphonate) | isoform IMPDH2, pH 8.0, 25°C | Homo sapiens |