Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GMP | competitive with respect to IMP, non competitive with respect to NAD+ and K+ | Klebsiella aerogenes | |
Li+ | competitive to K+ | Klebsiella aerogenes | |
NADH | poor inhibitor, product inhibition, non competitive | Klebsiella aerogenes | |
nicotinic acid | inhibitory analog of NAD+, non-competitive with respect to IMP and K+ | Klebsiella aerogenes | |
xanthosine 5'-phosphate | competitive with respect to IMP, non competitive with respect to NAD and K+ | Klebsiella aerogenes |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella aerogenes | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
IMP + NAD+ + H2O = XMP + NADH + H+ | IMP and K+ can bind randomly to the free enzyme, while NAD+ does not react unless K+ or both K+ and IMP are present on the enzyme | Klebsiella aerogenes | |
IMP + NAD+ + H2O = XMP + NADH + H+ | mechanism is partially random | Klebsiella aerogenes |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Klebsiella aerogenes | xanthosine 5'-phosphate + NADH | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Klebsiella aerogenes |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Klebsiella aerogenes |