Literature summary for 1.1.1.205 extracted from

Cooney, D.A.; Jayaram, H.N.; Glazer, R.I.; Kelley, J.A.; Marquez, V.E.; Gebeyehu, G.; Van Cott, A.C.; Zwelling, L.A.; Johns, D.G.
Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity (1983), Adv. Enzyme Regul., 21, 271-303.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	dinucleotide analogs of NAD	Escherichia coli
thiazole-4-carboxamide adenine dinucleotide	reversible inhibition	Escherichia coli
tiazofurin	-	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.59	-	thiazole-4-carboxamide adenine dinucleotide	chemically synthesized thiazole-4-carboxamide adenine dinucleotide	Escherichia coli
0.59	-	thiazole-4-carboxamide adenine dinucleotide	with thiazole-4-carboxamide adenine dinucleotide synthesized chemically	Escherichia coli
0.65	-	thiazole-4-carboxamide adenine dinucleotide	enzymatically synthesized thiazole-4-carboxamide adenine dinucleotide	Escherichia coli
0.65	-	thiazole-4-carboxamide adenine dinucleotide	with thiazole-4-carboxamide adenine dinucleotide synthesized enzymatically	Escherichia coli
1.03	-	thiazole-4-carboxamide adenine dinucleotide	ex vivo thiazole-4-carboxamide adenine dinucleotide	Escherichia coli
1.03	-	thiazole-4-carboxamide adenine dinucleotide	with thiazole-4-carboxamide adenine dinucleotide isolated ex vivo	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
IMP + thiazole-4-carboxamide adenine dinucleotide + H2O	-	Escherichia coli	XMP + reduced thiazole-4-carboxamide adenine dinucleotide + H+	-	r
inosine 5'-phosphate + NAD+ + H2O	-	Escherichia coli	xanthosine 5'-phosphate + NADH	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Escherichia coli
thiazole-4-carboxamide adenine dinucleotide	-	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000123	-	thiazole-4-carboxamide adenine dinucleotide	chemically synthesized thiazole-4-carboxamide adenine dinucleotide	Escherichia coli
0.000226	-	thiazole-4-carboxamide adenine dinucleotide	enzymatically synthesized thiazole-4-carboxamide adenine dinucleotide	Escherichia coli
0.000345	-	thiazole-4-carboxamide adenine dinucleotide	ex vivo thiazole-4-carboxamide adenine dinucleotide	Escherichia coli

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Release 2023.1 (January 2023)