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Literature summary for 1.1.1.2 extracted from
- The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity (1996), Biochemistry, 35, 14276-14280.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,3'-tetramethylenglutaric acid | - |
Homo sapiens |  |
| AL1576 | - |
Homo sapiens | |
| Alrestatin | - |
Homo sapiens | |
| FK366 | - |
Homo sapiens | |
| ponalrestat | - |
Homo sapiens | |
| sorbinil | - |
Homo sapiens | |
| Tolrestat | - |
Homo sapiens | |
| zopolrestat | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.038 | - |
p-Carboxybenzaldehyde | wild-type aldehyde reductase | Homo sapiens | |
| 0.11 | - |
p-Carboxybenzaldehyde | aldehyde reductase, mutant R308A | Homo sapiens | |
| 0.16 | - |
p-nitrobenzaldehyde | wild-type aldehyde reductase | Homo sapiens | |
| 0.17 | - |
Succinic semialdehyde | wild-type aldehyde reductase | Homo sapiens | |
| 0.2 | - |
Succinic semialdehyde | aldehyde reductase, mutant R308A | Homo sapiens | |
| 0.25 | - |
p-nitrobenzaldehyde | aldehyde reductase, mutant R308A | Homo sapiens | |
| 0.38 | - |
p-nitrobenzaldehyde | mutant R311A | Homo sapiens | |
| 1.7 | - |
DL-glyceraldehyde | wild-type aldehyde reductase | Homo sapiens | |
| 1.7 | - |
DL-glyceraldehyde | wild type enzyme, at pH 7.0 and 25°C | Homo sapiens | |
| 2.2 | - |
DL-glyceraldehyde | aldehyde reductase, mutant R311A | Homo sapiens | |
| 2.2 | - |
DL-glyceraldehyde | mutant enzyme R311A, at pH 7.0 and 25°C | Homo sapiens | |
| 2.3 | - |
DL-glyceraldehyde | aldehyde reductase, mutant R308A | Homo sapiens | |
| 2.3 | - |
DL-glyceraldehyde | mutant enzyme R308A, at pH 7.0 and 25°C | Homo sapiens | |
| 4 | - |
p-Carboxybenzaldehyde | aldehyde reductase, mutant R311A | Homo sapiens | |
| 4.2 | - |
D-glucuronate | wild-type aldehyde reductase | Homo sapiens | |
| 7.5 | - |
D-glucuronate | aldehyde reductase, mutant R308A | Homo sapiens | |
| 14.1 | - |
Succinic semialdehyde | aldehyde reductase, mutant R311A | Homo sapiens | |
| 364 | - |
D-glucuronate | aldehyde reductase, mutant R311A | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
| succinic semialdehyde + NADPH + H+ | Homo sapiens | - |
4-hydroxybutyrate + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P14550 | human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
| DL-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| p-carboxybenzaldehyde + NADPH | - |
Homo sapiens | p-carboxybenzyl alcohol + NADP+ | - |
r | |
| p-nitrobenzaldehyde + NADPH | - |
Homo sapiens | p-nitrobenzylalcohol + NADP+ | - |
? | |
| succinic semialdehyde + NADPH + H+ | - |
Homo sapiens | 4-hydroxybutyrate + NADP+ | - |
r | |
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