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Literature summary for 1.1.1.2 extracted from
- Purification and properties of aldehyde reductases from human placenta (1985), Biochim. Biophys. Acta, 840, 324-333.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Li2SO4 | both aldehyde reductase I and II are susceptible to inhibition | Homo sapiens |  |
| NaCl | aldehyde reductase I and II | Homo sapiens | |
| sorbinil | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
3-Pyridinecarboxaldehyde | AR I | Homo sapiens | |
| 0.02 | - |
NADPH | AR II | Homo sapiens | |
| 0.05 | - |
NADPH | AR I | Homo sapiens | |
| 0.07 | - |
glyceraldehyde | AR I | Homo sapiens | |
| 0.07 | - |
glyceraldehyde | aldehyde reductase I, at pH 7.3 and 37°C | Homo sapiens | |
| 0.21 | - |
propionaldehyde | AR I | Homo sapiens | |
| 2.53 | - |
glucuronate | AR II | Homo sapiens | |
| 2.63 | - |
propionaldehyde | AR II | Homo sapiens | |
| 6.67 | - |
glyceraldehyde | AR II | Homo sapiens | |
| 6.67 | - |
glyceraldehyde | aldehyde reductase II, at pH 7.0 and 37°C | Homo sapiens | |
| 8.61 | - |
3-Pyridinecarboxaldehyde | AR II | Homo sapiens | |
| 215 | - |
D-glucose | AR I | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32500 | - |
1 * 32500, SDS-PAGE | Homo sapiens |
| 32500 | - |
1 * 32500 + 1 * 39000 | Homo sapiens |
| 32700 | - |
aldehyde reductase II, gel filtration | Homo sapiens |
| 39000 | - |
1 * 32500 + 1 * 39000 | Homo sapiens |
| 74000 | - |
aldehyde reductase I, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucuronate + NADPH | Cavia porcellus | - |
L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | Homo sapiens | - |
L-gulonate + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Cavia porcellus | - |
glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | Homo sapiens | - |
glycerol + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
guinea pig | - |
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| aldehyde reductase I and II | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Cavia porcellus | - |
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-pyridinecarboxaldehyde + NADPH | - |
Cavia porcellus | 3-pyridinemethanol + NADP+ | - |
r | |
| 3-pyridinecarboxaldehyde + NADPH | - |
Homo sapiens | 3-pyridinemethanol + NADP+ | - |
r | |
| D-glucose + NADPH | placenta aldehyde reductase I | Homo sapiens | ? + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
? | |
| D-glucuronate + NADPH | - |
Cavia porcellus | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | - |
Homo sapiens | L-gulonate + NADP+ | - |
r | |
| D-glucuronate + NADPH | aldehyde reductase II | Homo sapiens | L-gulonate + NADP+ | - |
? | |
| D-glyceraldehyde + NADPH + H+ | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
| D-glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| glyceraldehyde + NADPH + H+ | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | - |
Cavia porcellus | glycerol + NADP+ | - |
r | |
| L-glyceraldehyde + NADPH | - |
Homo sapiens | glycerol + NADP+ | - |
r | |
| propionaldehyde + NADPH | - |
Homo sapiens | propanol + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 32500 + 1 * 39000 | Homo sapiens |
| monomer | 1 * 32500, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aldo-keto reductase | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
aldehyde reductaseI | Homo sapiens |
| 7 | - |
aldehyde reductase II | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | aldehyde reductase I | Homo sapiens | |
| NADPH | aldehyde reductase II utilizes only NADPH as cofactor | Homo sapiens | |
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