Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.2 extracted from

  • Das, B.; Srivastava, S.K.
    Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte (1985), Arch. Biochem. Biophys., 238, 670-679.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(NH4)2SO4
-
Homo sapiens
3,3'-tetramethylenglutaric acid
-
Homo sapiens
Alrestatin
-
Homo sapiens
Li2SO4 0.4 mM completely inhibits aldehyde reductase II Homo sapiens
N-ethylmaleimide
-
Homo sapiens
p-hydroxymercuribenzoate
-
Homo sapiens
quercetrin
-
Homo sapiens
sodium phenobarbital
-
Homo sapiens
sorbinil
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
NADPH aldehyde reductase II Homo sapiens
0.29
-
3-Pyridinecarboxaldehyde aldehyde reductase II Homo sapiens
2.5
-
glucuronate aldehyde reductase II Homo sapiens
7.59
-
glyceraldehyde aldehyde reductase II Homo sapiens
14.54
-
propionaldehyde aldehyde reductase II Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32500
-
gel filtration, Sephadex G-100 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucuronate + NADPH Homo sapiens
-
L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Homo sapiens
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Homo sapiens
-
glycerol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-

Purification (Commentary)

Purification (Comment) Organism
aldehyde reductase II Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
erythrocyte
-
Homo sapiens
-
liver
-
Homo sapiens
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-pyridinecarboxaldehyde + NADPH
-
Homo sapiens 3-pyridinemethanol + NADP+
-
r
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
?
D-glucuronate + NADPH
-
Homo sapiens L-gulonate + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Homo sapiens glycerol + NADP+
-
r
additional information enzyme is virtually inactive for aldo-sugars Homo sapiens ?
-
?
propionaldehyde + NADPH
-
Homo sapiens propanol + NADP+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 32500, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
L-hexonate dehydrogenase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
aldehyde reductase II Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
completely inactivated between 5 min Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
aldehyde reductase II Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH aldehyde reductase II utilizes only NADPH as cofactor Homo sapiens