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Literature summary for 1.1.1.188 extracted from

  • Endo, S.; Matsunaga, T.; Hara, A.
    Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity (2019), Arch. Biochem. Biophys., 674, 108096 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
P85W mutagenesis to the corresponding residue in other mammalian AKR1C subfamily enzymes, results in broad substrate specificity for nonsteroidal carbonyls and alcohols Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
benzbromarone
-
Mus musculus
estradiol
-
Mus musculus
Ethacrynic acid
-
Mus musculus
Flufenamic acid
-
Mus musculus
additional information less than 10% inhibition at 0.05 mM: phenolphthalein, hexestrol, medroxyprogesterone acetate, progesterone, testosterone, cortisol, dehydroepiandrosterone Mus musculus
quercetin
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0027
-
NADPH wild-type, pH 7, 37°C Mus musculus
0.003
-
Prostaglandin D2 wild-type, pH 7, 37°C Mus musculus
0.03
-
9alpha,11beta-prostaglandin F2 wild-type, pH 7, 37°C Mus musculus
0.28
-
9alpha,11beta-prostaglandin F2 mutant P85W, pH 7, 37°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D5U2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland abundant expression Mus musculus
-
brain low expression level Mus musculus
-
lung low expression level Mus musculus
-
ovary abundant expression Mus musculus
-
prostate gland low expression level Mus musculus
-
small intestine low expression level Mus musculus
-
testis abundant expression Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
9alpha,11beta-prostaglandin F2 + NADPH + H+
-
Mus musculus prostaglandin D2 + NADP+
-
r
prostaglandin D2 + NADP+
-
Mus musculus 9alpha,11beta-prostaglandin F2 + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
Akr1cl
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.007
-
9alpha,11beta-prostaglandin F2 mutant P85W, pH 7, 37°C Mus musculus
0.055
-
9alpha,11beta-prostaglandin F2 wild-type, pH 7, 37°C Mus musculus
0.093
-
Prostaglandin D2 wild-type, pH 7, 37°C Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7 prostaglandin D2 reductase activity Mus musculus
9.5
-
9alpha,11beta-prostaglandin F2 dehydrogenase activity Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0087
-
wild-type, pH 7, 37°C Mus musculus estradiol
0.014
-
wild-type, pH 7, 37°C Mus musculus quercetin
0.018
-
wild-type, pH 7, 37°C Mus musculus benzbromarone
0.037
-
wild-type, pH 7, 37°C Mus musculus Ethacrynic acid
0.054
-
wild-type, pH 7, 37°C Mus musculus Flufenamic acid