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Literature summary for 1.1.1.188 extracted from

  • Sun, S.Q.; Gu, X.; Gao, X.S.; Li, Y.; Yu, H.; Xiong, W.; Yu, H.; Wang, W.; Li, Y.; Teng, Y.; Zhou, D.
    Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation (2016), Oncotarget, 7, 48050-48058.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information establishment of a stable overexpressing AKR1C3 cell line (AKR1C3-over) derived from the prostate cell line DU145 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
indomethacin
-
Homo sapiens
additional information combination of indomethacin with tert-butyl hydroperoxide significantly inhibits the growth of radiation-resistant AKR1C3-over cells Homo sapiens
tert-butyl hydroperoxide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P42330
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
AKR1C3
-
Homo sapiens
aldo-keto reductase 1C3
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in prostaglandins metabolism. The produced PGF2alpha can not only promote prostate cancer cell's proliferation but also enhance prostate cancer cells resistance to radition. Overexpression of AKR1C3 significantly enhances human prostate cancer cells PCa resistance to radiation (or tert-butyl hydroperoxide) through activation of MAPK pathway. AKR1C3 has a pivotal role in the radioresistance of esophageal cancer and non-small-cell lung cancer Homo sapiens