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Literature summary for 1.1.1.188 extracted from

  • Mantel, A.; Newsome, A.; Thekkudan, T.; Frazier, R.; Katdare, M.
    The role of aldo-keto reductase 1C3 (AKR1C3)-mediated prostaglandin D2 (PGD2) metabolism in keloids (2016), Exp. Dermatol., 25, 38-43.
    View publication on PubMed
Search for more literature for 1.1.1.188

Inhibitors

Inhibitors Comment Organism Structure
15-deoxy-DELTA12,14-prostaglandin J2 15d-PGJ2, the enzyme inhibitor attenuates proliferation, inhibits collagen gel contraction and induces activation of the apoptotic marker, caspase-3, in CRL1762 keloid fibroblasts Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ Homo sapiens
-
 (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?
additional information Homo sapiens AKR1C3 is overexpressed in keloids and mediates the conversion of PGD2 to 9alpha,11beta-PGF2 in keloid and normal fibroblasts ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P42330
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-

Source Tissue

Source Tissue Comment Organism Textmining
CCD1113Sk cell
-
 Homo sapiens
-
fibroblast
-
 Homo sapiens
-
KEL-FIB cell keloid fibroblasts Homo sapiens
-
keloid
-
 Homo sapiens
-
myofibroblast
-
 Homo sapiens
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skin AKR1C3 is overexpressed in the fibrotic area of keloids (scarfs) while relatively weak staining is detected in normal skin Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
 Homo sapiens (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+
-
 ?
additional information AKR1C3 is overexpressed in keloids and mediates the conversion of PGD2 to 9alpha,11beta-PGF2 in keloid and normal fibroblasts Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AKR1C3
-
 Homo sapiens
aldo-keto reductase 1C3
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the enzyme inhibitor 15-deoxy-delta12,14-prostaglandin J2 attenuates proliferation, inhibits collagen gel contraction and induces activation of the apoptotic marker, caspase-3, in CRL1762 keloid fibroblasts, overview Homo sapiens
physiological function The major eicosanoid secreted by mast cells is prostaglandin D2 (PGD2), a relatively unstable pro-inflammatory mediator which can be spontaneously converted to 15-deoxy-(Delta12,14)-prostaglandin J2(15d-PGJ2) or enzymatically metabolized to 9alpha,11beta-PGF2 by aldo-keto reductase 1C3 (AKR1C3). Role of enzyme AKR1C3-mediated prostaglandin D2 (PGD2) metabolism in keloids, overview. Keloids are progressively expanding scars, mostly prevalent in individuals of African descent. Metabolism of PGD2 to 9a,11b-PGF2 by both, keloids and normal fibroblasts, is dependent on AKR1C3 Homo sapiens