Literature summary for 1.1.1.188 extracted from

Bresson, E.; Boucher-Kovalik, S.; Chapdelaine, P.; Madore, E.; Harvey, N.; Laberge, P.Y.; Leboeuf, M.; Fortier, M.A.
The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium (2011), J. Clin. Endocrinol. Metab., 96, 210-219.

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Inhibitors

Inhibitors	Comment	Organism	Structure
ponalrestat	specific inhibitor developed to block AKR1B1 activity. Application reduces prostaglandin F2alpha production in response to interleukin IL-1beta in both cultured endometrial cells and endometrial explants	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endometrial stromal cell	isoform AKR1B1 is expressed at a high level during the menstrual cycle during the secretory phase and in both epithelial and stromal cells	Homo sapiens	-
epithelium	isoform AKR1B1 is expressed at a high level during the menstrual cycle during the secretory phase and in both epithelial and stromal cells	Homo sapiens	-

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Release 2023.1 (January 2023)