Literature summary for 1.1.1.188 extracted from

Gram, A.; Buechler, U.; Boos, A.; Hoffmann, B.; Kowalewski, M.P.
Biosynthesis and degradation of canine placental prostaglandins: prepartum changes in expression and function of prostaglandin F2alpha-synthase (PGFS, AKR1C3) and 15-prostaglandin dehydrogenase (2013), Biol. Reprod., 89, 002.

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Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	isoform AKR1C3 expression is weak or absent in luteal samples	Canis lupus familiaris	-
placenta	utero/placental expression of isoform AKR1C3 is found in the superficial uterine glands throughout gestation and in the trophoblast cells within the feto-maternal contact zone during placentation	Canis lupus familiaris	-
uterus	uterine expression of isoforms AKR1C3 is up-regulated postimplantation and declines prepartum. Enzyme co-localizes with 15-prostaglandin dehydrogenase	Canis lupus familiaris	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	no activity with prostaglandin E2	Canis lupus familiaris	?	-	?
prostaglandin H2 + NADPH + H+	-	Canis lupus familiaris	prostaglandin F2alpha + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
prostaglandin F2alpha-synthase	-	Canis lupus familiaris

Expression

Organism	Comment	Expression
Canis lupus familiaris	uterine expression of isoforms AKR1C3 is up-regulated post implantation and declines prepartum	up

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Release 2023.1 (January 2023)