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Literature summary for 1.1.1.188 extracted from
- Prostaglandin F synthase (2002), Prostaglandins, 68-69, 401-407.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GSH | dependent on | Ovis aries |  |
| additional information | 4fold activation by heat treatment | Ovis aries |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| Y55F | complete elimination of PGD2, and PQ reductase activities, 27fold stimulation of PGH2 reductase activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 9,10-phenanthrenequinone | competitive inhibition of the PGD2 11-ketoreductase activity, not of PGH2 9-,11-endoperoxide reductase activity | Rattus norvegicus | |
| additional information | no inhibition by 9,10-phenanthrenequinone | Trypanosoma brucei |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Trypanosoma brucei | 5829 | - |
| membrane | associated | Ovis aries | 16020 | - |
| microsome | - |
Ovis aries | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 16000 | - |
1 * 16000 | Ovis aries |
| 17000 | - |
- |
Ovis aries |
| 33000 | - |
- |
Trypanosoma brucei |
| 36666 | - |
1 * 36666, lung enzyme, sequence calculation | Rattus norvegicus |
| 36670 | - |
lung enzyme, sequence calculation | Rattus norvegicus |
| 37000 | - |
lung and liver isozymes | Bos taurus |
| 37000 | - |
lung isozyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| prostaglandin D2 + NADPH + H+ | Homo sapiens | - |
prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | Rattus norvegicus | - |
prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | Bos taurus | - |
prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | Oryctolagus cuniculus | - |
prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin H2 + NADPH + H+ | Homo sapiens | - |
prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Rattus norvegicus | - |
prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Bos taurus | - |
prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Oryctolagus cuniculus | - |
prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Ovis aries | - |
prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Trypanosoma brucei | - |
prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | Bos taurus | enzyme also shows PGH2 9-,11-endoperoxide reductase activity | prostaglandin F2alpha + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
to isozymes in lung and liver | - |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Ovis aries | - |
- |
- |
| Rattus norvegicus | - |
two isozymes in lung and liver | - |
| Trypanosoma brucei | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| enzyme from lung, to homogeneity | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ | Tyr55 is critical for the reaction, the reactions with different substrates might follow different mechanisms | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | liver-type isozyme | Oryctolagus cuniculus | - |
| lung | - |
Rattus norvegicus | - |
| lung | - |
Bos taurus | - |
| lung | lung-type isozyme | Homo sapiens | - |
| lung | PGH2 9-,11-endoperoxide reductase activity lung-type isozyme | Bos taurus | - |
| seminal vesicle | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 9,10-phenanthrenequinone + NADPH | i.e. PQ | Homo sapiens | ? | - |
? | |
| 9,10-phenanthrenequinone + NADPH | i.e. PQ | Rattus norvegicus | ? | - |
? | |
| 9,10-phenanthrenequinone + NADPH | i.e. PQ | Bos taurus | ? | - |
? | |
| 9,10-phenanthrenequinone + NADPH | i.e. PQ | Oryctolagus cuniculus | ? | - |
? | |
| additional information | enzyme does not reduce prostaglandins D2 and E2 | Trypanosoma brucei | ? | - |
? | |
| additional information | enzyme shows no prostaglandin D2 11-ketoreductase activity, and no glutathione S-transferase activity, although it is similar to the glutathione S-transferase | Ovis aries | ? | - |
? | |
| prostaglandin D2 + NADPH + H+ | - |
Homo sapiens | prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Rattus norvegicus | prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Bos taurus | prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Oryctolagus cuniculus | prostaglandin 9alpha,11beta-F2 + NADP+ | product is involved in bronchial, vascular, and arterial smooth muscle contraction, product inhibits platelet aggregation and activates urinary excretion | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Homo sapiens | prostaglandin 9alpha,11beta-F2 + NADP+ | i.e. 11-epi PGF2alpha | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Rattus norvegicus | prostaglandin 9alpha,11beta-F2 + NADP+ | i.e. 11-epi PGF2alpha | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Bos taurus | prostaglandin 9alpha,11beta-F2 + NADP+ | i.e. 11-epi PGF2alpha | ? | |
| prostaglandin D2 + NADPH + H+ | - |
Oryctolagus cuniculus | prostaglandin 9alpha,11beta-F2 + NADP+ | i.e. 11-epi PGF2alpha | ? | |
| prostaglandin H2 + NADPH + H+ | - |
Homo sapiens | prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Rattus norvegicus | prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Bos taurus | prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Oryctolagus cuniculus | prostaglandin D2 + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Ovis aries | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Trypanosoma brucei | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | - |
Trypanosoma brucei | prostaglandin F2alpha + NADP+ | no stereochemic determination/identification of the product | ? | |
| prostaglandin H2 + NADPH + H+ | enzyme also shows PGH2 9-,11-endoperoxide reductase activity | Homo sapiens | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | enzyme also shows PGH2 9-,11-endoperoxide reductase activity | Rattus norvegicus | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | enzyme also shows PGH2 9-,11-endoperoxide reductase activity | Bos taurus | prostaglandin F2alpha + NADP+ | - |
? | |
| prostaglandin H2 + NADPH + H+ | enzyme also shows PGH2 9-,11-endoperoxide reductase activity | Oryctolagus cuniculus | prostaglandin F2alpha + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 16000 | Ovis aries |
| monomer | 1 * 36666, lung enzyme, sequence calculation | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme belongs to the AKR aldo-keto reductase superfamily | Trypanosoma brucei |
| More | enzyme belongs to the AKR aldo-keto-reductase superfamily | Homo sapiens |
| More | enzyme belongs to the AKR aldo-keto-reductase superfamily | Rattus norvegicus |
| More | enzyme belongs to the AKR aldo-keto-reductase superfamily | Bos taurus |
| More | enzyme belongs to the AKR aldo-keto-reductase superfamily | Oryctolagus cuniculus |
| PG endoperoxide reductase | - |
Ovis aries |
| PGD 11-ketoreductase | - |
Homo sapiens |
| PGD 11-ketoreductase | - |
Rattus norvegicus |
| PGD 11-ketoreductase | - |
Bos taurus |
| PGD 11-ketoreductase | - |
Oryctolagus cuniculus |
| PGD2 11-ketoreductase | - |
Homo sapiens |
| PGD2 11-ketoreductase | - |
Rattus norvegicus |
| PGD2 11-ketoreductase | - |
Bos taurus |
| PGD2 11-ketoreductase | - |
Oryctolagus cuniculus |
| PGF synthase | - |
Homo sapiens |
| PGF synthase | - |
Rattus norvegicus |
| PGF synthase | - |
Bos taurus |
| PGF synthase | - |
Oryctolagus cuniculus |
| PGF2alpha synthase | - |
Trypanosoma brucei |
| PGH 9-,11-endoperoxide reductase | - |
Ovis aries |
| PGH 9-,11-endoperoxide reductase | - |
Trypanosoma brucei |
| PGH2 9-,11-endoperoxide reductase | - |
Bos taurus |
| PGH2 9-,11-endoperoxide reductase | - |
Ovis aries |
| PGH2 9-,11-endoperoxide reductase | - |
Trypanosoma brucei |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | dependent on | Rattus norvegicus | |
| NADPH | dependent on | Bos taurus | |
| NADPH | dependent on | Oryctolagus cuniculus | |
| NADPH | dependent on | Ovis aries | |
| NADPH | dependent on | Trypanosoma brucei | |
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Release 2023.1 (January 2023)
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