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Literature summary for 1.1.1.184 extracted from

  • Moschini, R.; Rotondo, R.; Renzone, G.; Balestri, F.; Cappiello, M.; Scaloni, A.; Mura, U.; Del-Corso, A.
    Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes (2017), Chem. Biol. Interact., 276, 127-132 .
    View publication on PubMed
Search for more literature for 1.1.1.184

Inhibitors

Inhibitors Comment Organism Structure
daidzein 71% residual activity at 0.05 mM Homo sapiens
daidzin 74% residual activity at 0.05 mM Homo sapiens
genistein 63% residual activity at 0.05 mM Homo sapiens
quercetin
-
 Homo sapiens
quercitrin
-
 Homo sapiens
rutin
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0046
-
 9,10-phenantrenequinone at pH 8.4 and 37°C Homo sapiens
0.0065
-
 glutathionyl-nonanal at pH 8.4 and 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P16152
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-glutathionyl-4-hydroxynonanal + NADPH + H+
-
 Homo sapiens 3-glutathionyl-1,4-dihydroxynonane + NADP+
-
 ?
3-glutathionyl-4-hydroxynonanal hemiacetal + NADPH + H+
-
 Homo sapiens 3-glutathionyl-gamma-nonanolactone + NADP+
-
 ?
4-hydroxy-2-hexenal + NADPH + H+
-
 Homo sapiens ?
-
 ?
9,10-phenantrenequinone + NADPH + H+
-
 Homo sapiens ?
-
 ?
glutathionyl-nonanal + NADPH + H+
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
carbonyl reductase 1
-
 Homo sapiens
CBR1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
30.8
-
 glutathionyl-nonanal at pH 8.4 and 37°C Homo sapiens
66.7
-
 9,10-phenantrenequinone at pH 8.4 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00074
-
 at pH 8.4 and 37°C Homo sapiens rutin
0.00165
-
 at pH 8.4 and 37°C Homo sapiens quercetin
0.00182
-
 at pH 8.4 and 37°C Homo sapiens quercitrin