Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Canis lupus familiaris |
Protein Variants | Comment | Organism |
---|---|---|
D218V | single nucleotide polymorphism | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rutin | competitive | Canis lupus familiaris |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.104 | - |
daunorubicin | mutant D218V, pH 7.4, 37°C | Canis lupus familiaris | |
0.118 | - |
menadione | mutant D218V, pH 7.4, 37°C | Canis lupus familiaris | |
0.188 | - |
daunorubicin | wild-type, pH 7.4, 37°C | Canis lupus familiaris | |
0.527 | - |
menadione | wild-type, pH 7.4, 37°C | Canis lupus familiaris |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32800 | - |
- |
Canis lupus familiaris |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | J9P7P2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
daunorubicin + NADPH + H+ | - |
Canis lupus familiaris | daunorubicinol + NADP+ | - |
? | |
menadione + NADPH + H+ | - |
Canis lupus familiaris | ? + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 32800, SDS-PAGE, recombinant His-tagged protein | Canis lupus familiaris |
Synonyms | Comment | Organism |
---|---|---|
CBR1 | - |
Canis lupus familiaris |
LOC610164 | locus name | Canis lupus familiaris |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.12 | - |
menadione | mutant D218V, pH 7.4, 37°C | Canis lupus familiaris | |
1.12 | - |
daunorubicin | mutant D218V, pH 7.4, 37°C | Canis lupus familiaris | |
3.52 | - |
daunorubicin | wild-type, pH 7.4, 37°C | Canis lupus familiaris | |
8.48 | - |
menadione | wild-type, pH 7.4, 37°C | Canis lupus familiaris |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0014 | - |
mutant D218V, pH 7.4, 37°C | Canis lupus familiaris | rutin | |
0.0018 | - |
wild-type, pH 7.4, 37°C | Canis lupus familiaris | rutin |