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Literature summary for 1.1.1.184 extracted from

  • Molnari, J.; Myers, A.
    Carbonyl reduction of bupropion in human liver (2012), Xenobiotica, 42, 550-561.
    View publication on PubMed

Application

Application Comment Organism
medicine antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion in liver. Menadione and 18beta-glycyrrhetinic acid are inhibitory Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
18beta-glycyrrhetinic acid inhibits the reduction of bupropion in liver microsomes Homo sapiens
menadione inhibits the reduction of bupropion in liver cytosol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bupropion + NADPH + H+
-
Homo sapiens erythrohydrobupropion + NADP+ in liver cytosol, antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion ?
bupropion + NADPH + H+
-
Homo sapiens threohydrobupropion + NADP+ in liver cytosol, antidepressant bupropion is reduced to erythrohydrobupropion and threohydrobupropion ?