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Literature summary for 1.1.1.184 extracted from
- Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1 (2008), Mol. Cell. Biochem., 315, 113-121.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.038 | - |
NADPH | pH 6.5, 25°C | Homo sapiens |  |
| 0.043 | - |
menadione | pH 6.5, 25°C | Homo sapiens | |
| 0.13 | - |
4-nitrobenzaldehyde | pH 6.5, 25°C | Homo sapiens | |
| 0.3 | - |
4-benzoylpyridine | pH 6.5, 25°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | recombinant protein in HEK-293 cell | Homo sapiens | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
x * 40000, SDS-PAGE, His-tagged protein | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O75828 | isoform Cbr3, comparison with prostaglandin 9-ketoreductase Cbr1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| ovary | lower expression in prostate and testis than in ovary | Homo sapiens | - |
| pancreas | - |
Homo sapiens | - |
| prostate | lower expression in prostate and testis than in ovary | Homo sapiens | - |
| testis | lower expression in prostate and testis than in ovary | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-benzoylpyridine + NADPH + H+ | - |
Homo sapiens | (S)-alpha-phenyl-4-pyridylmethanol + NADP+ | - |
? | |
| 4-nitrobenzaldehyde + NADPH | - |
Homo sapiens | 4-nitrobenzyl alcohol + NADP+ | - |
? | |
| menadione + NADPH | - |
Homo sapiens | ? + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 40000, SDS-PAGE, His-tagged protein | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0092 | - |
menadione | pH 6.5, 25°C | Homo sapiens | |
| 0.0098 | - |
4-nitrobenzaldehyde | pH 6.5, 25°C | Homo sapiens | |
| 0.012 | - |
4-benzoylpyridine | pH 6.5, 25°C | Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7 | - |
Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | - |
15% of maximum activity | Homo sapiens |
| 8 | - |
35% of maximum activity | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
| NADH | with NADH, about 45% of the activity with NADPH | Homo sapiens | |
| NADP+ | - |
Homo sapiens | |
| NADPH | with NADH, about 45% of the activity with NADPH | Homo sapiens | |
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Release 2023.1 (January 2023)
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