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Literature summary for 1.1.1.178 extracted from
- 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease (2005), FEBS J., 272, 4874-4883.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | important in brain development and aging, SCHAD deficiency is an inherited defect in mitochondrial fatty acid oxidation, reported cases of SCHAD deficiency are actually due to a deficiency of HAD, abnormal levels may contribute to the pathogenesis of some neural disorders, potential target for intervention in Alzheimer's disease, Parkinson's disease, and an X-linked mental retardation | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L122V | affects brain development and brain function in patients | Homo sapiens |
| R130C | affects brain development and brain function in patients | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-azepan-1-yl-2-phenyl-2-(4-thioxo-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl)-ethanone | specific inhibitor of SCHAD, forms a covalent adduct with NAD+ by a catalytic suicide mechanism | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amygdala | - |
Homo sapiens | - |
| brain | expressed in different regions | Homo sapiens | - |
| brain | levels of SCHAD/HADII are significantly reduced in the ventral midbrain of a Parkinsons disease mouse model | Mus musculus | - |
| cerebral cortex | - |
Homo sapiens | - |
| hippocampus | - |
Homo sapiens | - |
| hypothalamus | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| spinal cord | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-methyl-3-hydroxybutyryl-CoA | among the best substrates | Rattus norvegicus | 2-methyl-acetoacetyl-CoA | - |
? | |
| additional information | acts on a wide spectrum of substrates, including steroids, cholic acids, and fatty acids, with a preference for short chain methyl-branched acyl-CoAs | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 17beta-hydroxysteroid dehydrogenase type 10 | - |
Mus musculus |
| 17beta-hydroxysteroid dehydrogenase type 10 | - |
Homo sapiens |
| 17beta-hydroxysteroid dehydrogenase type 10 | - |
Rattus norvegicus |
| 2-methyl-3-hydroxybutyryl-CoA dehydrogenase | - |
Homo sapiens |
| 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | - |
Homo sapiens |
| HADII | - |
Mus musculus |
| HADII | - |
Rattus norvegicus |
| HSD10 | - |
Mus musculus |
| HSD10 | - |
Rattus norvegicus |
| MHBD | - |
Homo sapiens |
| SCHAD | - |
Mus musculus |
| SCHAD | - |
Homo sapiens |
| SCHAD | - |
Rattus norvegicus |
| short chain 3-hydroxyacyl-CoA dehydrogenase | - |
Mus musculus |
| short chain 3-hydroxyacyl-CoA dehydrogenase | - |
Homo sapiens |
| short chain 3-hydroxyacyl-CoA dehydrogenase | - |
Rattus norvegicus |
| type II 3-hydroxyacyl-CoA dehydrogenase | - |
Mus musculus |
| type II 3-hydroxyacyl-CoA dehydrogenase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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