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Literature summary for 1.1.1.153 extracted from

  • Fujimoto, K.; Hara, M.; Yamada, H.; Sakurai, M.; Inaba, A.; Tomomura, A.; Katoh, S.
    Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase (2001), Chem. Biol. Interact., 130-132, 825-832.
    View publication on PubMed
Search for more literature for 1.1.1.153

Cloned(Commentary)

Cloned (Comment) Organism
site-directed mutagenesis, recombinant protein expressed in Escherichia coli GI724 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K175I decreased activity against a pteridine substrate and exogenous carbonyl compound Rattus norvegicus
S158D decreased activity against a pteridine substrate and exogenous carbonyl compound Rattus norvegicus
S158D/Y171V double-point mutant does not show any activity towards any substrate Rattus norvegicus
Y171V decreased activity against a pteridine substrate and exogenous carbonyl compound Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus
-
 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phenyl-1,2-propanedione + NADPH
-
 Rattus norvegicus ?
-
 ?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
 Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
 ?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
-
 Rattus norvegicus L-erythro-tetrahydrobiopterin + 2 NADP+
-
 ?
acetohexamide + NADPH
-
 Rattus norvegicus ?
-
 ?
menadione + NADPH
-
 Rattus norvegicus ?
-
 ?
p-nitrobenzaldehyde + NADPH
-
 Rattus norvegicus p-nitrobenzyl alcohol + NADP+
-
 ?
propiophenone + NADPH
-
 Rattus norvegicus ?
-
 ?