Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-keto,25-hydroxycholesterol | inhibits the oxoreduction of cortisone to cortisol by the recombinant isoform 11beta-HSD1 | Homo sapiens | |
7-keto,25-hydroxycholesterol | - |
Mus musculus | |
7alpha,25-Dihydroxycholesterol | - |
Homo sapiens | |
7beta,25-dihydroxycholesterol | - |
Homo sapiens | |
7beta,25-dihydroxycholesterol | - |
Mus musculus | |
glycyrrhetinic acid | - |
Homo sapiens | |
additional information | not inhibited by 7alpha,25-dihydroxycholesterol | Homo sapiens | |
additional information | isoform 11beta-HSD2 is not inhibited by 7alpha,25-dihydroxycholesterol | Mus musculus | |
T0504 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000029 | - |
7beta,25-dihydroxycholesterol | recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C | Homo sapiens | |
0.000556 | - |
7beta,25-dihydroxycholesterol | recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Mus musculus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 1 mM used in assay conditions | Homo sapiens | |
Mg2+ | 1 mM used in assay conditions | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NAD+ | Homo sapiens | - |
cortisone + NADH + H+ | - |
? | |
cortisol + NAD+ | Mus musculus | - |
cortisone + NADH + H+ | - |
? | |
cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Mus musculus | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Homo sapiens | P80365 | - |
- |
Mus musculus | P50172 | - |
- |
Mus musculus | P51661 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-keto,25-hydroxycholesterol + NADPH + H+ | - |
Homo sapiens | 7beta,25-dihydroxycholesterol + NADP+ | - |
? | |
7-keto,25-hydroxycholesterol + NADPH + H+ | - |
Mus musculus | 7beta,25-dihydroxycholesterol + NADP+ | - |
? | |
7-ketocholesterol + NADPH + H+ | - |
Homo sapiens | 7beta-hydroxycholesterol + NADP+ | - |
? | |
7-ketocholesterol + NADPH + H+ | - |
Mus musculus | 7beta-hydroxycholesterol + NADP+ | - |
? | |
7beta,25-dihydroxycholesterol + NAD+ | - |
Homo sapiens | 7-keto,25-hydroxycholesterol + NADH + H+ | - |
? | |
7beta,25-dihydroxycholesterol + NAD+ | - |
Mus musculus | 7-keto,25-hydroxycholesterol + NADH + H+ | - |
? | |
corticosterone + NAD+ | - |
Mus musculus | 11-dehydrocorticosterone + NADH + H+ | - |
? | |
cortisol + NAD+ | - |
Homo sapiens | cortisone + NADH + H+ | - |
? | |
cortisol + NAD+ | - |
Mus musculus | cortisone + NADH + H+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD1 | - |
Mus musculus |
11beta-HSD2 | - |
Homo sapiens |
11beta-HSD2 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 2 | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000049 | - |
recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C | Homo sapiens | 7-keto,25-hydroxycholesterol | |
0.000053 | - |
recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C | Mus musculus | 7-keto,25-hydroxycholesterol | |
0.000091 | - |
recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C | Homo sapiens | 7beta,25-dihydroxycholesterol | |
0.000119 | - |
recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C | Mus musculus | 7beta,25-dihydroxycholesterol | |
0.000405 | - |
recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C | Homo sapiens | 7-keto,25-hydroxycholesterol | |
0.002 | - |
IC50 of more than 0.002 mM, recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C | Mus musculus | 7-keto,25-hydroxycholesterol | |
0.003 | - |
IC50 of more than 0.003 mM, recombinant isoform 11beta-HSD1, at pH 7.4 and 37°C | Homo sapiens | 7beta,25-dihydroxycholesterol | |
0.003 | - |
recombinant isoform 11beta-HSD2, at pH 7.4 and 37°C | Mus musculus | 7beta,25-dihydroxycholesterol |