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Literature summary for 1.1.1.146 extracted from

  • Loerz, C.; Maser, E.
    The cortisol-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 in skeletal muscle in the pathogenesis of the metabolic syndrome (2017), J. Steroid Biochem. Mol. Biol., 174, 65-71 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
carbenoxolone
-
Homo sapiens
PF-877423
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens
-
cortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myoblast
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform 11beta-HSD1 enzyme activity is decreased in diabetic subjects down
Homo sapiens isoform 11beta-HSD1 mRNA expression and enzyme activity is up-regulated by physiological concentrations of cortisol. After treatment with dexamethasone, isoform 11beta-HSD1 mRNA expression increases in both diabetics and controls up

General Information

General Information Comment Organism
metabolism prereceptor glucocorticoid metabolism by 11beta-HSD1 is implicated in the pathogenesis of the metabolic syndrome Homo sapiens