Any feedback?
Literature summary for 1.1.1.146 extracted from
- Expression and activity of the cortisol-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 is tissue and species-specific (2019), Chem. Biol. Interact., 303, 57-61 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| carbenoxolone | - |
Homo sapiens |  |
| epigallocatechin gallate | - |
Homo sapiens | |
| glycyrrhetinic acid | - |
Homo sapiens | |
| Momordica charantia extract | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P28845 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Homo sapiens | - |
| brain | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| inflammatory cell | - |
Homo sapiens | - |
| leukocyte | - |
Homo sapiens | - |
| liver | highest expression | Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| uterus | - |
Homo sapiens | - |
| vasculature | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-HSD type 1 | - |
Homo sapiens |
| 11beta-HSD1 | - |
Homo sapiens |
| 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | dependent on | Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays important roles in the development of the metabolic syndrome as well as at the interface of inflammation and obesity | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
