Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-glucose 6-phosphate | stimulates isoform 11beta-HSD1 reductase activity in liver but not in testis | Rattus norvegicus | |
D-glucose 6-phosphate | stimulates isoform 11beta-HSD1 reductase activity in liver but not in testis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Leydig cell | - |
Rattus norvegicus | - |
Leydig cell | - |
Homo sapiens | - |
liver parenchymal cell | - |
Rattus norvegicus | - |
liver parenchymal cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH + H+ | - |
Rattus norvegicus | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? | |
additional information | in liver cells, isoform 11beta-HSD1 behaves as a primary reductase, while in Leydig cells it acts as a primary oxidase | Rattus norvegicus | ? | - |
? | |
additional information | in liver cells, isoform 11beta-HSD1 behaves as a primary reductase, while in Leydig cells it acts as a primary oxidase | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Rattus norvegicus |
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase 1 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus | |
NADPH | - |
Homo sapiens |