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Literature summary for 1.1.1.146 extracted from

  • Li, X.; Hu, G.; Li, X.; Wang, Y.Y.; Hu, Y.Y.; Zhou, H.; Latif, S.A.; Morris, D.J.; Chu, Y.; Zheng, Z.; Ge, R.S.
    Metabolic coupling determines the activity: comparison of 11beta-hydroxysteroid dehydrogenase 1 and its coupling between liver parenchymal cells and testicular Leydig cells (2015), PLoS ONE, 10, e0141767.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
D-glucose 6-phosphate stimulates isoform 11beta-HSD1 reductase activity in liver but not in testis Rattus norvegicus
D-glucose 6-phosphate stimulates isoform 11beta-HSD1 reductase activity in liver but not in testis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell
-
Rattus norvegicus
-
Leydig cell
-
Homo sapiens
-
liver parenchymal cell
-
Rattus norvegicus
-
liver parenchymal cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH + H+
-
Rattus norvegicus corticosterone + NADP+
-
?
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?
additional information in liver cells, isoform 11beta-HSD1 behaves as a primary reductase, while in Leydig cells it acts as a primary oxidase Rattus norvegicus ?
-
?
additional information in liver cells, isoform 11beta-HSD1 behaves as a primary reductase, while in Leydig cells it acts as a primary oxidase Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Rattus norvegicus
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase 1
-
Rattus norvegicus
11beta-hydroxysteroid dehydrogenase 1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus
NADPH
-
Homo sapiens