Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.146 extracted from

  • Schmidt, M.; Straub, R.H.
    11beta-Hydroxysteroid dehydrogenase enzymes modulate effects of glucocorticoids in rheumatoid arthritis synovial cells (2015), Neuroimmunomodulation, 22, 40-45.
    View publication on PubMed
Search for more literature for 1.1.1.146

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NADP+ Homo sapiens substrate for isoforms 11betaHSD1 and 11betaHSD2 cortisone + NADPH + H+
-
 ?
cortisone + NADPH + H+ Homo sapiens substrate for isoform 11betaHSD1 only cortisol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast isoform 11betaHSD1 Homo sapiens
-
lymphocyte isoform 11betaHSD2 Homo sapiens
-
macrophage isoform 11betaHSD2 Homo sapiens
-
osteoblast isoform 11betaHSD1 Homo sapiens
-
synovial tissue
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+ substrate for isoforms 11betaHSD1 and 11betaHSD2 Homo sapiens cortisone + NADPH + H+
-
 ?
cortisone + NADPH + H+ substrate for isoform 11betaHSD1 only Homo sapiens cortisol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
11betaHSD1 isoform Homo sapiens
11betaHSD2 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in rheumatoid arthritis up