Literature summary for 1.1.1.146 extracted from

Guo, J.; Deng, H.; Li, H.; Zhu, Q.; Zhao, B.; Chen, B.; Chu, Y.; Ge, R.S.
Effects of methoxychlor and its metabolite 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane on 11beta-hydroxysteroid dehydrogenase activities in vitro (2013), Toxicol. Lett., 218, 18-23.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane	competitive. Also inhibitory to isoform 11beta-HSD2	Homo sapiens
2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane	competitive. Also inhibitory to isoform 11beta-HSD2	Rattus norvegicus
methoxychlor	competitive. Not inhibitory to isoform 11beta-HSD2	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Homo sapiens	-	-
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28845	-	-
Rattus norvegicus	P16232	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-
testis	-	Rattus norvegicus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00191	-	37°C, pH not specified in the publication, microsomal assay	Homo sapiens	methoxychlor
0.00888	-	37°C, pH not specified in the publication, microsomal assay	Homo sapiens	2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane
0.00915	-	37°C, pH not specified in the publication, microsomal assay	Rattus norvegicus	2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane

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Release 2023.1 (January 2023)