Application | Comment | Organism |
---|---|---|
medicine | curcumin is inhibitory to isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one | derivative of curcumin, IC50 value in intact cells 93 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM | Homo sapiens | |
(1E,4E)-1,5-bis(thiophen-2-yl) penta-1,4-dien-3-one | derivative of curcumin, IC50 value in intact cells 184 nM. Not inhibitory to isoform 11beta-HSD2 in kidney at 100 microM | Rattus norvegicus | |
curcumin | inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 2.29 microM | Homo sapiens | |
curcumin | inhibitory against isoform 11beta-HSD1 in intact cells with IC50 value of 5.79 microM, competitive. Treatment with curcumin reduces serum glucose, cholesterol, triglyceride, low density lipoprotein levels in high-fat-diet-induced obese rats | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Rattus norvegicus | P16232 | - |
- |