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Literature summary for 1.1.1.146 extracted from

  • Dzyakanchuk, A.A.; Balazs, Z.; Nashev, L.G.; Amrein, K.E.; Odermatt, A.
    11beta-Hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP(+) and is stimulated by extracellular glucose (2009), Mol. Cell. Endocrinol., 301, 137-141.
    View publication on PubMed
Search for more literature for 1.1.1.146

Activating Compound

Activating Compound Comment Organism Structure
glucose coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity Mus musculus
glucose coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens
expressed in rat H4IIE hepatoma cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-
adipocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+
-
 Mus musculus cortisone + NADPH
-
 r
cortisol + NADP+
-
 Homo sapiens cortisone + NADPH
-
 r

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
 Mus musculus
11beta-HSD1
-
 Homo sapiens
11beta-hydroxysteroid dehydrogenase 1
-
 Mus musculus
11beta-hydroxysteroid dehydrogenase 1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+ 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ Mus musculus
NADP+ 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ Homo sapiens
NADPH 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ Mus musculus
NADPH 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ Homo sapiens