Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity | Mus musculus | |
Insulin | insulin stimulates 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the p38 MAPK inhibitor SB-220025, but not the ERK inhibitor U-0126 or the phosphatidylinositol 3-kinase inhibitor LY294002, prevent insulin stimulation of 11beta-HSD1 activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dexamethasone | dexmethasone inhibits 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the effect of dexamethasone is mimicked by both cortisol and corticosterone but blocked by the glucocorticoid receptor antagonist RU486 | Mus musculus | |
dexamethasone | dexmethasone inhibits 11beta-HSD1 activity and expression in a time- and concentration-dependent manner, the effect of dexamethasone is mimicked by both cortisol and corticosterone but blocked by the glucocorticoid receptor antagonist RU486 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
white adipose tissue | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | - |
Mus musculus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | - |
Rattus norvegicus | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Rattus norvegicus | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Rattus norvegicus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Rattus norvegicus |