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Literature summary for 1.1.1.146 extracted from

  • Czegle, I.; Piccirella, S.; Senesi, S.; Csala, M.; Mandl, J.; Banhegyi, G.; Fulceri, R.; Benedetti, A.
    Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum (2006), Mol. Cell. Endocrinol., 248, 24-25.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum lumen Rattus norvegicus 5783
-
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Rattus norvegicus isozyme 11beta-HSD1 might play an important role in the metabolic syndrome cortisol + NADP+
-
r
additional information Rattus norvegicus isozyme 11beta-HSD1 and hexose-6-phosphate dehydrogenase are co-localized in the hepatic endoplasmic reticulum and act in close cooperation in generation of cofactors for each other, functional coupling, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+ isozyme 11beta-HSD1 Rattus norvegicus cortisol + NADP+
-
r
cortisone + NADPH + H+ isozyme 11beta-HSD1 might play an important role in the metabolic syndrome Rattus norvegicus cortisol + NADP+
-
r
additional information isozyme 11beta-HSD1 and hexose-6-phosphate dehydrogenase are co-localized in the hepatic endoplasmic reticulum and act in close cooperation in generation of cofactors for each other, functional coupling, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 1
-
Rattus norvegicus
11betaHSD1
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Rattus norvegicus
NADPH
-
Rattus norvegicus