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Literature summary for 1.1.1.146 extracted from

  • Odermatt, A.; Atanasov, A.G.; Balazs, Z.; Schweizer, R.A.; Nashev, L.G.; Schuster, D.; Langer, T.
    Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1 (2006), Mol. Cell. Endocrinol., 248, 15-23.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information a cytoplasmic localized mutant of isozyme 11beta-HSD1 catalyzes the oxoreduction of cortisone, but not of 7-oxocholesterol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane luminal orientation, physiological relevance of the membrane topology of 11beta-HSD1 Homo sapiens 5789
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens isozyme 11beta-HSD1 cortisol + NADP+
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?
additional information Homo sapiens isozyme 11beta-HSD1 is essential for local activation of glucocorticoid receptors, compartimentalization is important for its regulation by hexose-6-phosphate dehydrogenase, metabolic regulation, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845 isozyme 11beta-HSD1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7-oxocholesterol + NADPH + H+ isozyme 11beta-HSD1, stereospecific reaction Homo sapiens 7beta-hydroxycholesterol + NADP+
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?
cortisone + NADPH + H+ isozyme 11beta-HSD1 Homo sapiens cortisol + NADP+
-
?
additional information isozyme 11beta-HSD1 is essential for local activation of glucocorticoid receptors, compartimentalization is important for its regulation by hexose-6-phosphate dehydrogenase, metabolic regulation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
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Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
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Homo sapiens