Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.146 extracted from

  • Ayachi, S.E.; Paulmyer-Lacroix, O.; Verdier, M.; Alessi, M.C.; Dutour, A.; Grino, M.
    11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women (2006), J. Thromb. Haemost., 4, 621-627.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glycyrrhetinic acid
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens biological transformation of inactive cortisone to active cortisol cortisol + NADP+
-
?
additional information Homo sapiens isozyme 11beta-HSD1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1, PAI-1, in adipose tissue of obese women ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
obese women
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue expression of isozyme 11beta-HSD1, in situ hybridization, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?
cortisone + NADPH + H+ biological transformation of inactive cortisone to active cortisol Homo sapiens cortisol + NADP+
-
?
additional information isozyme 11beta-HSD1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1, PAI-1, in adipose tissue of obese women Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens