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Literature summary for 1.1.1.146 extracted from

  • Li, W.; Gao, L.; Wang, Y.; Duan, T.; Myatt, L.; Sun, K.
    Enhancement of cortisol-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by interleukin 1beta in cultured human chorionic trophoblast cells (2006), Endocrinology, 147, 2490-2495.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information isozyme 11beta-HSD1 is induced by cortisol, mechanism through induction of promoter activity, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH cortisol + NADP+
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme 11beta-HSD1
-

Source Tissue

Source Tissue Comment Organism Textmining
chorion chorionic trophoblast cell Homo sapiens
-
trophoblast chorionic trophoblast cell Homo sapiens
-
uterus expression of isozyme 11beta-HSD1 in intrauterine tissue, overview Homo sapiens
-
WISH cell amnion-derived cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+ isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH Homo sapiens cortisol + NADP+
-
ir

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH 11beta-HSD1 Homo sapiens