Cloned (Comment) | Organism |
---|---|
expression in Sf9 cells | Homo sapiens |
expression of the isozyme type II in Spodoptera frugiperda Sf9 cells using the baculovirus transfection system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-hydroxyflavone | 0.00056 mM, 50% inhibition; competitive | Homo sapiens | |
apigenin | 0.13 mM, 50% inhibition | Homo sapiens | |
Biochanin A | 0.00094 mM, 50% inhibition | Homo sapiens | |
cyanoketone | 0.0000076 mM, 50% inhibition; competitive | Homo sapiens | |
daidzein | 0.0033 mM, 50% inhibition | Homo sapiens | |
flavanones | diverse derivatives, inhibitory potential determination, overview | Homo sapiens | |
flavones | diverse derivatives, inhibitory potential determination, overview | Homo sapiens | |
formononetin | 0.0032 mM, 50% inhibition | Homo sapiens | |
genistein | 0.00026 mM, 50% inhibition; competitive | Homo sapiens | |
isoflavones | diverse derivatives, inhibitory potential determination, overview | Homo sapiens | |
additional information | structure-inhibition relationship | Homo sapiens | |
myricetin | 0.011 mM, 50% inhibition | Homo sapiens | |
quercetin | 0.084 mM, 50% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0018 | - |
dehydroepiandrosterone | 37°C, pH 7.4 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | Homo sapiens | - |
androst-5-en-3,17-dione + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a 3beta-hydroxy-DELTA5-steroid + NAD+ = a 3-oxo-DELTA5-steroid + NADH + H+ | structure-function relationship | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-HSD type II | - |
Homo sapiens |
3beta-hydroxysteroid dehydrogenase type II | - |
Homo sapiens |
3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000067 | - |
cyanoketone | recombinant enzyme | Homo sapiens | |
0.00000067 | - |
cyanoketone | 37°C, pH 7.4 | Homo sapiens | |
0.00012 | - |
genistein | recombinant enzyme | Homo sapiens | |
0.00012 | - |
genistein | 37°C, pH 7.4 | Homo sapiens | |
0.00019 | - |
6-hydroxyflavone | recombinant enzyme | Homo sapiens | |
0.00019 | - |
6-hydroxyflavone | 37°C, pH 7.4 | Homo sapiens |