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Literature summary for 1.1.1.145 extracted from
- Bovine adrenal 3beta-hydroxysteroid dehydrogenase (E.C. 1.1.1.145)/5-ene-4-ene isomerase (E.C. 5.3.3.1): characterization and its inhibition by isoflavones (1999), J. Steroid Biochem. Mol. Biol., 71, 191-202.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 17beta-estradiol | - |
Bos taurus |  |
| apigenin | - |
Bos taurus | |
| Biochanin A | - |
Bos taurus | |
| daidzein | - |
Bos taurus | |
| daidzein | - |
Cricetinae | |
| formononetin | - |
Bos taurus | |
| genistein | - |
Bos taurus | |
| prunetin | - |
Bos taurus | |
| puerarin | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
dehydroepiandrosterone | - |
Bos taurus | |
| 0.001 | - |
allopregnanolone | - |
Bos taurus | |
| 0.001 | - |
androstenediol | - |
Bos taurus | |
| 0.002 | - |
pregnenolone | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pregnenolone + NAD(P)+ | Bos taurus | - |
pregn-5-en-3,20-dione + NAD(P)H + H+ | - |
? | |
| pregnenolone + NAD(P)+ | Cricetinae | - |
pregn-5-en-3,20-dione + NAD(P)H + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cricetinae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+ | - |
Bos taurus | 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H | - |
? | |
| 3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+ | - |
Cricetinae | 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H | - |
? | |
| 5alpha-pregnan-3beta-ol-20-one + NAD+ | - |
Bos taurus | 5alpha-pregnan-3,20-dione + NADH | - |
? | |
| allopregnanolone + NAD+ | - |
Bos taurus | ? | - |
r | |
| androstenediol + NAD+ | - |
Bos taurus | testosterone + NADH + H+ | - |
r | |
| dehydroepiandrosterone + NAD+ | - |
Bos taurus | androst-5-en-3,17-dione + NADH + H+ | - |
? | |
| pregnenolone + NAD(P)+ | - |
Bos taurus | pregn-5-en-3,20-dione + NAD(P)H + H+ | - |
? | |
| pregnenolone + NAD(P)+ | - |
Cricetinae | pregn-5-en-3,20-dione + NAD(P)H + H+ | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0233 | - |
allopregnanolone | - |
Bos taurus | |
| 0.0333 | - |
dehydroepiandrosterone | - |
Bos taurus | |
| 0.0333 | - |
androstenediol | - |
Bos taurus | |
| 0.04 | - |
pregnenolone | - |
Bos taurus | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bos taurus | |
| NAD+ | - |
Cricetinae | |
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Release 2023.1 (January 2023)
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