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Literature summary for 1.1.1.145 extracted from

  • Koritz, S.B.
    The conversion of pregnenolone to progesterone by small particles from rat adrenal (1964), Biochemistry, 3, 1098-1102.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
NAD+
-
Rattus norvegicus
13
-
NADP+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + NAD(P)+ Rattus norvegicus
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
Rattus norvegicus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
?
additional information no reaction with OH in 17alpha, 17beta, 20alpha, 20beta position Rattus norvegicus ?
-
?
pregnenolone + NAD(P)+
-
Rattus norvegicus pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+ preferred Rattus norvegicus
NADP+ 33times less effective than NAD+ Rattus norvegicus