Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.141 extracted from

  • Yao, L.; Chen, W.; Song, K.; Han, C.; Gandhi, C.R.; Lim, K.; Wu, T.
    15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury (2017), PLoS ONE, 12, e0176106 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.141

Application

Application Comment Organism
drug development induction of 15-hydroxyprostaglandin dehydrogenase expression or utilization of 15-keto-PGE2 analogue may have therapeutic benefits for the treatment of endotoxin-associated liver inflammation/injury Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Mus musculus the enzyme catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the proinflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-gamma]) (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VCC1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver generation of transgenic mice with targeted expression of 15-hydroxyprostaglandin dehydrogenase in the liver Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ the enzyme catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the proinflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-gamma]) Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Mus musculus
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mus musculus

General Information

General Information Comment Organism
metabolism NAD+-dependent 15-hydroxyprostaglandin dehydrogenase protects against LPS/GalN-induced liver injury and the effect is mediated via 15-keto-PGE2, which activates PPAR-gamma in Kupffer cells and thus inhibits their ability to produce inflammatory cytokines Mus musculus