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Literature summary for 1.1.1.141 extracted from

  • Lee, J.; Zhong, X.; Lee, J.; Surh, Y.; Na, H.
    15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells (2020), Arch. Biochem. Biophys., 679, 108162 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
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 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15428
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCD-841 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
15-PGDH
-
 Homo sapiens
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is a tumor suppressor in various malignancies including colon cancer. The product (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate (15-keto PGE2) stimulates the Nrf2-HO-1 axis through the generation of ROS in normal colon epithelial cells, which contributes to the potential role of this lipid mediator in preventing cancer development associated with oxidative stress and inflammatory tissue damage Homo sapiens