Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | bile acids activate the signal transduction pathway protein kinase C-> extracellular signal-regulated kinase 1/2-> early growth response factor-1-> Snail and thereby suppress 15-PGDH transcription, unconjugated bile acids are much more potent inhibitors of 15-PGDH expression and activity than related conjugated bile acids, chenodeoxycholate and deoxycholate suppress the transcription of 15-PGDH resulting in reduced amounts of mRNA, protein, and enzyme activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
colonocyte | - |
Homo sapiens | - |
HCT-15 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
15-hydroxyprostaglandin + NAD+ | - |
Homo sapiens | 15-oxoprostaglandin + NADH + H+ | - |
? | |
prostaglandin E2 + NAD+ | - |
Homo sapiens | 15-ketoprostaglandin E2 + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Homo sapiens |
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | dependent on | Homo sapiens |