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Literature summary for 1.1.1.141 extracted from

  • Tai, H.H.; Cho, H.; Tong, M.; Ding, Y.
    NAD+-linked 15-hydroxyprostaglandin dehydrogenase: structure and biological functions (2006), Curr. Pharm. Des., 12, 955-962.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence, expression analysis and transcriptional regulation, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information identfication of catalytically important residues by site-directed mutagenesis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens transcriptional regulation and biological functions, the enzyme cooperates with cyclooxygenase-2 to control cellular prostaglandin levels, reciprocal regulation of the two enzymes, overview (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Reaction

Reaction Comment Organism Reaction ID
(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ = (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ residues and domains involved in catalysis and substrate binding, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ transcriptional regulation and biological functions, the enzyme cooperates with cyclooxygenase-2 to control cellular prostaglandin levels, reciprocal regulation of the two enzymes, overview Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
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?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2, inactivation Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
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?

Subunits

Subunits Comment Organism
More molecular modeling Homo sapiens

Synonyms

Synonyms Comment Organism
15-PGDH
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Homo sapiens
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens