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Literature summary for 1.1.1.141 extracted from

  • Wolf, I.; OKelly, J.; Rubinek, T.; Tong, M.; Nguyen, A.; Lin, B.T.; Tai, H.H.; Karlan, B.Y.; Koeffler, H.P.
    15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer (2006), Cancer Res., 66, 7818-7823.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme up-regulation by the tumor suppressor gene CAAT/enhancer binding protein alpha Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme silencing by RNAi method Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information enzyme down-regulation by estrogen Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens catabolism of (15S)-PGE2 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
additional information Homo sapiens the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell expression of the enzyme and the estrogen receptor is correlated Homo sapiens
-
BT-474 cell
-
Homo sapiens
-
MCF-7 cell high enzyme expression level Homo sapiens
-
MDA-MB-231 cell low enzyme expression level Homo sapiens
-
T-47D cell
-
Homo sapiens
-
ZR75-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ catabolism of (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
additional information the enzyme is a tumor suppressor of human breast cancer, expression of the enzyme and the estrogen receptor is correlated, silencing of the enzyme results in enhanced cancer cell proliferation, the enzyme expression is silenced in vivo in cancer cells due to promoter methylation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens
15-PGDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens