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Literature summary for 1.1.1.141 extracted from

  • Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.
    Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase (2005), Arch. Biochem. Biophys., 433, 447-453.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
I17A 270% of wild-type activity Homo sapiens
I17E no activity Homo sapiens
I17K no activity Homo sapiens
I17L 364% of wild-type activity Homo sapiens
I17V 300% of wild-type activity Homo sapiens
N91A 136% of wild-type activity Homo sapiens
N91D 86% of wild-type activity Homo sapiens
N91K no activity Homo sapiens
N91L no activity Homo sapiens
V186A 143% of wild-type activity Homo sapiens
V186D no activity Homo sapiens
V186I 468% of wild-type activity Homo sapiens
V186K 71% of wild-type activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, I17L mutant Homo sapiens
0.0026
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, N91D mutant Homo sapiens
0.0034
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5 Homo sapiens
0.0035
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, V186K mutant Homo sapiens
0.0045
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, V186A mutant Homo sapiens
0.006
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, N91A mutant Homo sapiens
0.011
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, I17A mutant Homo sapiens
0.011
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, I17V mutant Homo sapiens
0.022
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, V186I mutant Homo sapiens
0.022
-
NAD+ 37°C, pH 7.5, V186K mutant Homo sapiens
0.024
-
NAD+ 37°C, pH 7.5, V186A mutant Homo sapiens
0.032
-
NAD+ 37°C, pH 7.5, N91D mutant Homo sapiens
0.038
-
NAD+ 37°C, pH 7.5 Homo sapiens
0.059
-
NAD+ 37°C, pH 7.5, I17L mutant Homo sapiens
0.098
-
NAD+ 37°C, pH 7.5, I17V mutant Homo sapiens
0.27
-
NAD+ 37°C, pH 7.5, V186I mutant Homo sapiens
0.55
-
NAD+ 37°C, pH 7.5, I17A mutant Homo sapiens
0.72
-
NAD+ 37°C, pH 7.5, N91A mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant 15-PGDH Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
15-PGDH
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
35
-
NAD+ 37°C, pH 7.5, V186K mutant Homo sapiens
37
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, V186K mutant Homo sapiens
42
-
NAD+ 37°C, pH 7.5, N91D mutant Homo sapiens
45
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, N91D mutant Homo sapiens
47
-
NAD+ 37°C, pH 7.5 Homo sapiens
50
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5 Homo sapiens
70
-
NAD+ 37°C, pH 7.5, V186A mutant Homo sapiens
73
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, N91A mutant Homo sapiens
78
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, V186A mutant Homo sapiens
91
-
NAD+ 37°C, pH 7.5, N91A mutant Homo sapiens
110
-
NAD+ 37°C, pH 7.5, I17V mutant Homo sapiens
127
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, I17A mutant Homo sapiens
129
-
NAD+ 37°C, pH 7.5, I17A mutant Homo sapiens
143
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, I17V mutant Homo sapiens
165
-
NAD+ 37°C, pH 7.5, I17L mutant Homo sapiens
210
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, I17L mutant Homo sapiens
247
-
NAD+ 37°C, pH 7.5, V186I mutant Homo sapiens
262
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate 37°C, pH 7.5, V186I mutant Homo sapiens