Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
I17A | 270% of wild-type activity | Homo sapiens |
I17E | no activity | Homo sapiens |
I17K | no activity | Homo sapiens |
I17L | 364% of wild-type activity | Homo sapiens |
I17V | 300% of wild-type activity | Homo sapiens |
N91A | 136% of wild-type activity | Homo sapiens |
N91D | 86% of wild-type activity | Homo sapiens |
N91K | no activity | Homo sapiens |
N91L | no activity | Homo sapiens |
V186A | 143% of wild-type activity | Homo sapiens |
V186D | no activity | Homo sapiens |
V186I | 468% of wild-type activity | Homo sapiens |
V186K | 71% of wild-type activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, I17L mutant | Homo sapiens | |
0.0026 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, N91D mutant | Homo sapiens | |
0.0034 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5 | Homo sapiens | |
0.0035 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, V186K mutant | Homo sapiens | |
0.0045 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, V186A mutant | Homo sapiens | |
0.006 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, N91A mutant | Homo sapiens | |
0.011 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, I17A mutant | Homo sapiens | |
0.011 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, I17V mutant | Homo sapiens | |
0.022 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, V186I mutant | Homo sapiens | |
0.022 | - |
NAD+ | 37°C, pH 7.5, V186K mutant | Homo sapiens | |
0.024 | - |
NAD+ | 37°C, pH 7.5, V186A mutant | Homo sapiens | |
0.032 | - |
NAD+ | 37°C, pH 7.5, N91D mutant | Homo sapiens | |
0.038 | - |
NAD+ | 37°C, pH 7.5 | Homo sapiens | |
0.059 | - |
NAD+ | 37°C, pH 7.5, I17L mutant | Homo sapiens | |
0.098 | - |
NAD+ | 37°C, pH 7.5, I17V mutant | Homo sapiens | |
0.27 | - |
NAD+ | 37°C, pH 7.5, V186I mutant | Homo sapiens | |
0.55 | - |
NAD+ | 37°C, pH 7.5, I17A mutant | Homo sapiens | |
0.72 | - |
NAD+ | 37°C, pH 7.5, N91A mutant | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | - |
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant 15-PGDH | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
35 | - |
NAD+ | 37°C, pH 7.5, V186K mutant | Homo sapiens | |
37 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, V186K mutant | Homo sapiens | |
42 | - |
NAD+ | 37°C, pH 7.5, N91D mutant | Homo sapiens | |
45 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, N91D mutant | Homo sapiens | |
47 | - |
NAD+ | 37°C, pH 7.5 | Homo sapiens | |
50 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5 | Homo sapiens | |
70 | - |
NAD+ | 37°C, pH 7.5, V186A mutant | Homo sapiens | |
73 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, N91A mutant | Homo sapiens | |
78 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, V186A mutant | Homo sapiens | |
91 | - |
NAD+ | 37°C, pH 7.5, N91A mutant | Homo sapiens | |
110 | - |
NAD+ | 37°C, pH 7.5, I17V mutant | Homo sapiens | |
127 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, I17A mutant | Homo sapiens | |
129 | - |
NAD+ | 37°C, pH 7.5, I17A mutant | Homo sapiens | |
143 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, I17V mutant | Homo sapiens | |
165 | - |
NAD+ | 37°C, pH 7.5, I17L mutant | Homo sapiens | |
210 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, I17L mutant | Homo sapiens | |
247 | - |
NAD+ | 37°C, pH 7.5, V186I mutant | Homo sapiens | |
262 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, V186I mutant | Homo sapiens |