Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.141 extracted from

  • Xun, C.Q.; Ensor, C.M.; Tai, H.H.
    Regulation of synthesis and activity of NAD+-dependent 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) by dexamethasone and phorbol ester in human erythroleukemia (HEL) cells (1991), Biochem. Biophys. Res. Commun., 177, 1258-1265.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
corticosterone 4fold activation Homo sapiens
cortisone 5fold activation Homo sapiens
dexamethasone 10fold activation Homo sapiens
estradiol 2fold activation Homo sapiens
additional information 12-O-tetradecanoylphorbol-13-acetate induces the synthesis of 15-PGDH but inhibits the enzyme activity a protein kinase C mediated mechanism Homo sapiens
Prednisolone 6fold activation Homo sapiens
progesterone activates, 7fold activation Homo sapiens
testosterone 2fold activation Homo sapiens
Triamcinolone 7fold activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
12-O-tetradecanoylphorbol-13-acetate 10 nM, rapid loss of activity in eryrthroleukemia cells during 40 min, inhibition can be prevented by staurosporin indicating that protein kinase C is involved; induces the synthesis of 15-PGDH but inhibits the enzyme activity a protein kinase C mediated mechanism Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
additional information Homo sapiens dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
enzyme expression is induced in human eryrthroleukemia cells by dexamethasone
-

Source Tissue

Source Tissue Comment Organism Textmining
HEL cell erythroleukemia cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
additional information dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
15-PGDH
-
Homo sapiens
NAD+-linked 15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens