Activating Compound | Comment | Organism | Structure |
---|---|---|---|
corticosterone | 4fold activation | Homo sapiens | |
cortisone | 5fold activation | Homo sapiens | |
dexamethasone | 10fold activation | Homo sapiens | |
estradiol | 2fold activation | Homo sapiens | |
additional information | 12-O-tetradecanoylphorbol-13-acetate induces the synthesis of 15-PGDH but inhibits the enzyme activity a protein kinase C mediated mechanism | Homo sapiens | |
Prednisolone | 6fold activation | Homo sapiens | |
progesterone | activates, 7fold activation | Homo sapiens | |
testosterone | 2fold activation | Homo sapiens | |
Triamcinolone | 7fold activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
12-O-tetradecanoylphorbol-13-acetate | 10 nM, rapid loss of activity in eryrthroleukemia cells during 40 min, inhibition can be prevented by staurosporin indicating that protein kinase C is involved; induces the synthesis of 15-PGDH but inhibits the enzyme activity a protein kinase C mediated mechanism | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | - |
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
additional information | Homo sapiens | dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
enzyme expression is induced in human eryrthroleukemia cells by dexamethasone | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEL cell | erythroleukemia cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or (15S)-PGE2 | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
additional information | dexamethasone and phorbol ester play a role in enzyme regulation in erythroleukemia cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Homo sapiens |
NAD+-linked 15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |