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Literature summary for 1.1.1.133 extracted from

  • Wang, Y.; Hess, T.N.; Jones, V.; Zhou, J.Z.; McNeil, M.R.; Andrew McCammon, J.
    Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening (2011), Bioorg. Med. Chem. Lett., 21, 7064-7067.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.133

Inhibitors

Inhibitors Comment Organism Structure
2,6,7-trihydroxy-9-(2-hydroxyphenyl)-3H-xanthen-3-one
-
 Mycobacterium tuberculosis
2,6,7-trihydroxy-9-methyl-3H-xanthen-3-one
-
 Mycobacterium tuberculosis
2,6,7-trihydroxy-9-phenyl-3H-xanthen-3-one
-
 Mycobacterium tuberculosis
5-ethenyl-1-methyl-9,10-dihydrophenanthrene-2,7-diol
-
 Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Synonyms

Synonyms Comment Organism
dTDP-6-deoxy-L-lyxo-4-hexulose reductase
-
 Mycobacterium tuberculosis
RmlD
-
 Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 2,6,7-trihydroxy-9-phenyl-3H-xanthen-3-one
0.0015
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 2,6,7-trihydroxy-9-methyl-3H-xanthen-3-one
0.0021
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 2,6,7-trihydroxy-9-(2-hydroxyphenyl)-3H-xanthen-3-one
0.0025
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 5-ethenyl-1-methyl-9,10-dihydrophenanthrene-2,7-diol