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Literature summary for 1.1.1.132 extracted from

  • Elloumi, N.; Moreau, B.; Aguiar, L.; Jaziri, N.; Sauvage, M.; Hulen, C.; Capmau, M.L.
    Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains (1992), Eur. J. Med. Chem., 27, 149-154.
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Inhibitors

Inhibitors Comment Organism Structure
5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
5'-azido-5'-deoxy-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
5'-azido-5'-deoxy-N2-2',3'-O-triacetylguanosine only after preincubation with enzyme Pseudomonas aeruginosa
5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine GDP-analog, 0.1 mM, 60% inhibition Pseudomonas aeruginosa
guanosine slight inhibition only after preincubation with enzyme Pseudomonas aeruginosa
additional information strains which resist 0.005 mg/ml of tobramycin treated by 5'-(3-hydroxypropyl)-amino-5'-deoxy-guanosine, tetra-O-acetylmannopyranose and 5'[[[[(2'',3'',4'',6''-tetra-O-acetyl 6''-ethynyl)alpha-D-mannopyranosyl oxy]-carbonyl]amino]sulfonyl]-2',3'-isopropylidene N2-acetyl guanosine recover 20, 75 and 85% of their sensisivity towards tobramycin Pseudomonas aeruginosa
N2-acetyl-2',3'-isopropylidene guanosine only after preincubation with enzyme Pseudomonas aeruginosa
N2-acetyl-5'-amino-5'-deoxy-2',3'-O-acetylguanosine only after preincubation with enzyme Pseudomonas aeruginosa
N2-acetyl-5'-amino-5'-deoxy-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
N2-acetyl-guanosine only after preincubation with enzyme Pseudomonas aeruginosa
tetra-O-acetylmannopyranose GDP-analog, 0.1 mM, 75% inhibition Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
 A22 alg+, selected from mucoid strain IPA22
-

Purification (Commentary)

Purification (Comment) Organism
protamine sulfate precipitation, gel exclusion, ion exchange chromatography Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-mannose + NAD+ + H2O
-
 Pseudomonas aeruginosa GDP-mannuronate + NADH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Pseudomonas aeruginosa