Literature summary for 1.1.1.132 extracted from

Tavares, I.M.; Leitao, J.H.; Fialho, A.M.; Sa-Correia, I.
Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa (1999), Res. Microbiol., 150, 105-116.

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	mucoid strains of cystic fibrosis patients 8821, its high-alginate-producing spontaneously variant 8821M, IST23, IST27 and IST30, mucoid strains derived from the spontaneous nonmucoid strains during prolonged incubation under nutrient limitation in acetamide broth (Nm), rich in PolyP, no activity in spontaneous swiched nonmucoid variants (N) of initial isolated mucoid strains	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.002	0.015	mucoid forms, activity correlated with alginate production and level of transcription of algD gene	Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GDP-mannose + NAD+ + H2O	-	Pseudomonas aeruginosa	GDP-mannuronate + NADH	-	ir

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)