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Literature summary for 1.1.1.108 extracted from
- An inducible carnitine dehydrogenase from Pseudomonas aeruginosa (1967), Biochim. Biophys. Acta, 139, 505-507.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hydrazine hydrate | 30 mM, 70% inhibition | Pseudomonas aeruginosa |  |
| hydroxylamine | 1 mM, complete inhibition | Pseudomonas aeruginosa | |
| p-chloromercuribenzoate | 0.1 mM, complete inhibition | Pseudomonas aeruginosa | |
| Sodium borate | 20 mM, 60% inhibition | Pseudomonas aeruginosa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.042 | - |
NAD+ | - |
Pseudomonas aeruginosa | |
| 8.5 | - |
L-carnitine | - |
Pseudomonas aeruginosa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | Pseudomonas aeruginosa | - |
3-dehydrocarnitine + NADH + H+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-hydroxy-4-trimethylaminobutyrate + NAD+ | - |
Pseudomonas aeruginosa | 3-dehydrocarnitine + NADH + H+ | - |
r | |
| carnitine + NAD+ | - |
Pseudomonas aeruginosa | 3-dehydrocarnitine + NADH + H+ | - |
r | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | 9.5 | - |
Pseudomonas aeruginosa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Pseudomonas aeruginosa | |
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