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Literature summary for 1.1.1.101 extracted from
- Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides (1972), J. Biol. Chem., 247, 5825-5834.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | activation, acyldihydroxyacetone phosphate as substrate | Cavia porcellus |  |
| EDTA | activation, acyldihydroxyacetone phosphate as substrate | Rattus norvegicus | |
General Stability
| General Stability | Organism |
|---|---|
| freeze-thawing, stable after several cycles | Cavia porcellus |
| freeze-thawing, stable after several cycles | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | - |
NADPH | cosubstrate hexadecyldihydroxyacetone phosphate, brain | Rattus norvegicus | |
| 0.007 | - |
NADPH | cosubstrate palmitoyldihydroxyacetone phosphate, brain | Rattus norvegicus | |
| 0.01 | - |
NADPH | ascites microsomes | Cavia porcellus | |
| 0.01 | - |
NADPH | ascites microsomes | Rattus norvegicus | |
| 0.05 | - |
NADPH | liver mitochondria | Cavia porcellus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyldihydroxyacetone phosphate + NADPH | Cavia porcellus | reaction in non-ether lipids biosynthesis | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| acyldihydroxyacetone phosphate + NADPH | Rattus norvegicus | reaction in non-ether lipids biosynthesis | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| alkyldihydroxyacetone phosphate + NADPH + H+ | Cavia porcellus | reaction in ether lipids biosynthesis | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| alkyldihydroxyacetone phosphate + NADPH + H+ | Rattus norvegicus | reaction in ether lipids biosynthesis | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| ascites tumor cell | grown in the abdomen of swiss white mice | Cavia porcellus | - |
| ascites tumor cell | grown in the abdomen of swiss white mice | Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Cavia porcellus | - |
| spleen | - |
Cavia porcellus | - |
| testis | - |
Cavia porcellus | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyldihydroxyacetone phosphate + NADPH | - |
Cavia porcellus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| acyldihydroxyacetone phosphate + NADPH | - |
Rattus norvegicus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| acyldihydroxyacetone phosphate + NADPH | reaction in non-ether lipids biosynthesis | Cavia porcellus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| acyldihydroxyacetone phosphate + NADPH | reaction in non-ether lipids biosynthesis | Rattus norvegicus | 1-acyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| alkyldihydroxyacetone phosphate + NADPH + H+ | - |
Cavia porcellus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| alkyldihydroxyacetone phosphate + NADPH + H+ | - |
Rattus norvegicus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| alkyldihydroxyacetone phosphate + NADPH + H+ | reaction in ether lipids biosynthesis | Cavia porcellus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| alkyldihydroxyacetone phosphate + NADPH + H+ | reaction in ether lipids biosynthesis | Rattus norvegicus | 1-alkyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| hexadecyldihydroxyacetone phosphate + NADPH | - |
Cavia porcellus | 1-hexadecyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| hexadecyldihydroxyacetone phosphate + NADPH | - |
Rattus norvegicus | 1-hexadecyl-sn-glycerol 3-phosphate + NADP+ | - |
? | |
| palmitoylglycerone phosphate + NADPH | i.e. palmitoyldihydroxyacetone phosphate | Cavia porcellus | 1-palmitoylglycerol 3-phosphate + NADP+ | - |
? | |
| palmitoylglycerone phosphate + NADPH | i.e. palmitoyldihydroxyacetone phosphate | Rattus norvegicus | 1-palmitoylglycerol 3-phosphate + NADP+ | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 100 | - |
complete inactivation after 10 min | Cavia porcellus |
| 100 | - |
complete inactivation after 10 min | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | broad optimum | Cavia porcellus |
| 6.5 | 7.5 | broad optimum | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Cavia porcellus | |
| NADH | at high concentrations, rat liver | Rattus norvegicus | |
| NADPH | specific for NADPH | Cavia porcellus | |
| NADPH | specific for NADPH | Rattus norvegicus | |
| NADPH | hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates | Cavia porcellus | |
| NADPH | hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates | Rattus norvegicus | |
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