Literature summary for 1.1.1.1 extracted from

Biswas, R.; Prabhu, S.; Lynd, L.R.; Guss, A.M.
Increase in ethanol yield via elimination of lactate production in an ethanol-tolerant mutant of Clostridium thermocellum (2014), PLoS ONE, 9, e86389.

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Application

Application	Comment	Organism
synthesis	deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. The engineered strain retains tolerance to 5% v/v ethanol, resulting in an ethanol tolerant platform strain	Acetivibrio thermocellus

Organism

Organism	UniProt	Comment	Textmining
Acetivibrio thermocellus	A3DCI2	-	-
Acetivibrio thermocellus DSM 1237	A3DCI2	-	-

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Release 2023.1 (January 2023)