Literature summary for 1.1.1.1 extracted from

De Bolle, X.; Vinals, C.; Fastrez, J.; Feytmans, E.
Bivalent cations stabilize yeast alcohol dehydrogenase I (1997), Biochem. J., 323, 409-413.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
three-dimensional model of the enzyme structure suggest that Ca2+ can be displaced by replacing Met-168 by an Arg residue	Saccharomyces cerevisiae

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	CaCl2 and MgCl2 are able to stabilize the enzyme at millimolar concentrations. Ca2+ stabilizes yeast ADH I by preventing the dissociation of the reduced form of the enzyme and by preventing the unfolding of the oxidized form of the enzyme. Ca2+ is fixed by the Asp236 and Glu101 side chains in yeast ADH I	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Synonyms

Synonyms	Comment	Organism
ADH I	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)