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Literature summary for 1.1.1.1 extracted from

  • Blacklock, T.J.; Sohar, P.; Butcher, J.W.; Lamanec, T.; Grabowski, E.J.J.
    An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507:5,6-dihydro-(s)-4-(ethylamino)-(s)-6-mehtyl-4H-thieno[2,3-beta]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride (1993), J. Org. Chem., 58, 1672-1679.
No PubMed abstract available

Application

Application Comment Organism
synthesis production of (4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7dioxide, which is an intermediate in the synthesis of the carbonic anhydrase inhibitor trusopt. Trusopt is a novel, topically active treatment for glaucoma Neurospora crassa

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6S)-5,6-dihydro-6-methyl-4H-thieno[2,3b]thiopyran-4-one-7,7-dioxide + NADH + H+
-
Neurospora crassa (4S,6S)-5,6-dihydro-4-hydroxy-6-methyl-4H-thieno[2,3b]thiopyran-7,7-dioxide + NAD+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
33
-
-
Neurospora crassa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
3.8
-
-4.3 Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
NADH
-
Neurospora crassa