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Ligand pyruvate kinase Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C4 2 H6 6 N1 0 O8 R2
pyruvate kinase
LRUPROVAHFMXQZ-JDQHVGNYSA-N
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (2 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
phosphopyruvate kinase + H2O = pyruvate kinase + phosphate
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[pyruvate kinase] phosphate + H2O = pyruvate kinase + phosphate
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Substrate in Enzyme-catalyzed Reactions (2 results)
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ATP + pyruvate kinase = ADP + phosphorylated pyruvate kinase
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ATP + pyruvate kinase = ADP + phospho-[pyruvate kinase]
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Product in Enzyme-catalyzed Reactions (3 results)
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reduced pyruvate kinase + O2 = pyruvate kinase + H2O
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phosphopyruvate kinase + H2O = pyruvate kinase + phosphate
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[pyruvate kinase] phosphate + H2O = pyruvate kinase + phosphate
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Activator in Enzyme-catalyzed Reactions (1 result)
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builds complex with Pra with specific GTP synthesis activity
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Enzyme Kinetic Parameters
References & Links Literature References (6)
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Purification and characterization of a protein phosphatase that dephosphorylates pyruvate kinase in an anoxia tolerant animal
1996
Brooks, S.P.J.; Storey, K.B.
Biochem. Mol. Biol. Int.
38
1223-1234
Pyruvate kinase phosphatase
1981
Jett, M.F.; Hue, L.; Hers, H.G.
FEBS Lett.
132
183-186
Stimulation of pyruvate kinase phosphatase activity by insulin in isolated rat hepatocytes
1986
Lopez-Alarcon, L.; Mojena, M.; Monge, L.; Feliu, J.E.
Biochem. Biophys. Res. Commun.
134
292-298
The effect of cAMP and cGMP on the activity and substrate specificity of protein kinase A from methylotrophic yeast Pichia pastoris
2003
Frajnt, M.; Cytrynska, M.; Jakubowicz, T.
Acta Biochim. Pol.
50
1111-1118
Characterization of membrane-associated Pseudomonas aeruginosa Ras-like protein Pra, a GTP-binding protein that forms complexes with truncated nucleoside diphosphate kinase and pyruvate kinase to modulate GTP synthesis
1997
Chopade, B.A.; Shankar, S.; Sundin, G.W.; Mukhopadhyay, S.; Chakrabarty, A.M.
J. Bacteriol.
179
2181-2188
Unveiling the novel dual specificity protein kinases in Bacillus anthracis
2012
Arora, G.; Sajid, A.; Arulanandh, M.D.; Singhal, A.; Mattoo, A.R.; Pomerantsev, A.P.; Leppla, S.H.; Maiti, S.; Singh, Y.
J. Biol. Chem.
287
26749-26763
Links to other databases for pyruvate kinase
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